In this article, we will closely examine how Microsoft Defender, a security model that quickly adapts to the reality of the world we live in, allows all organizations and governmental entities to appropriately secure their environments whether they are on Azure or on-premises. We will also demonstrate how to leverage the cloud security posture management feature in Microsoft Defender to ensure maintaining a proper security posture and being compliant with various regulatory compliance such as FedRAMP, CMMC, and CIS.